Affordable Access

A prospective trial of prophylactic intravenous immune globulin for the prevention of infections in severely burned patients.

Authors
  • Waymack, J P
  • Jenkins, M E
  • Alexander, J W
  • Warden, G D
  • Miller, A C
  • Carey, M
  • Ogle, C K
  • Kopcha, R G
Type
Published Article
Journal
Burns
Publisher
Elsevier
Publication Date
Apr 01, 1989
Volume
15
Issue
2
Pages
71–76
Identifiers
PMID: 2500137
Source
Medline
License
Unknown

Abstract

A prospective randomized double-blind study evaluated the efficacy of i.v. immune globulin in preventing infectious complications in severely burned patients. Fifty patients were randomized to receive either i.v. immune globulin or placebo. Each group of patients was treated with twice weekly infusions for either 5 weeks or until the patients' wounds were covered. Patients treated with the immune globulin had an immediate correction of their depressed serum IgG levels, however there was no change in the infection or mortality rates. No adverse effects were noted with the immune globulin treatments. One potential weakness of this study was the greater burn surface area and a higher incidence of inhalation injury in adult patients treated with i.v. immune globulin compared to controls.

Report this publication

Statistics

Seen <100 times