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A prospective randomized study to assess the efficacy of rate and site of atrial pacing on long-term development of atrial fibrillation.

Authors
  • Lau, Chu-Pak
  • Wang, Chun-Chieh
  • Ngarmukos, Tachapong
  • Kim, You-Ho
  • Kong, Chi-Woon
  • Omar, Razali
  • Sriratanasathavorn, Charn
  • Munawar, Muhammad
  • Kam, Ruth
  • Lee, Kathy Lf
  • Lau, Elizabeth Oi-Yan
  • Tse, Hung-Fat
Type
Published Article
Journal
Journal of Cardiovascular Electrophysiology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Sep 01, 2009
Volume
20
Issue
9
Pages
1020–1025
Identifiers
DOI: 10.1111/j.1540-8167.2009.01484.x
PMID: 19460078
Source
Medline
License
Unknown

Abstract

The Septal Pacing for Atrial Fibrillation Suppression Evaluation (SAFE) study is a single-blinded, parallel randomized designed multicenter study in pacemaker indicated patients with paroxysmal atrial fibrillation (AF). The objective is to evaluate whether the site of atrial pacing--conventional right atrial appendage versus low atrial septal--with or without atrial overdrive pacing will influence the development of persistent AF. The study will provide a definitive answer to whether a different atrial pacing site or the use of AF suppression pacing or both can give incremental antiarrhythmic benefit when one is implanting a device for a patient with a history of paroxysmal AF.

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