Affordable Access

deepdyve-link
Publisher Website

Prospective longitudinal patient-reported outcomes of swallowing following intensity modulated proton therapy for oropharyngeal cancer.

Authors
  • Grant, Stephen R1
  • Hutcheson, Katherine A2
  • Ye, Rong3
  • Garden, Adam S1
  • Morrison, William H1
  • Rosenthal, David I1
  • Brandon Gunn, G1
  • Fuller, C David1
  • Phan, Jack1
  • Reddy, Jay P1
  • Moreno, Amy C1
  • Lewin, Jan S2
  • Sturgis, Erich M2
  • Ferrarotto, Renata4
  • Frank, Steven J5
  • 1 Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, United States. , (United States)
  • 2 Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, United States. , (United States)
  • 3 Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, United States. , (United States)
  • 4 Department of Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, United States. , (United States)
  • 5 Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, United States. Electronic address: [email protected] , (United States)
Type
Published Article
Journal
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Publication Date
Apr 21, 2020
Volume
148
Pages
133–139
Identifiers
DOI: 10.1016/j.radonc.2020.04.021
PMID: 32361662
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

With an enlarging population of long-term oropharyngeal cancer survivors, dysphagia is an increasingly important toxicity following oropharynx cancer treatment. While lower doses to normal surrounding structures may be achieved with intensity modulated proton therapy (IMPT) compared to photon-based radiation, the clinical benefit is uncertain. Seventy-one patients with stage III/IV oropharyngeal cancer (AJCC 7th edition) undergoing definitive IMPT on a longitudinal prospective cohort study who had completed the MD Anderson Dysphagia Inventory (MDADI) at pre-specified time points were included. The majority of patients had HPV-positive tumors (85.9%) and received bilateral neck radiation (81.4%) with concurrent systemic therapy (61.8%). Mean composite MDADI scores decreased from 88.2 at baseline to 59.6 at treatment week 6, and then increased to 74.4 by follow up week 10, 77.0 by 6 months follow up, 80.5 by 12 months follow up, and 80.1 by 24 months follow up. At baseline, only 5.6% of patients recording a poor composite score (lower than 60), compared to 61.2% at treatment week 6, 19.1% at follow up week 10, 13.0% at 6 months follow up, 13.5% at 1 year follow up, and 11.1% at 2 years follow up. Patient reported outcomes following IMPT for oropharyngeal cancer demonstrates decreased swallowing function at completion of treatment with relatively rapid recovery by 10 weeks follow up and steady improvement through 2 years. The results are comparable to similar longitudinal studies of photon-based radiotherapy for oropharynx cancer, and suggest that IMPT confers no additional excess toxicity related to swallowing. Copyright © 2020 Elsevier B.V. All rights reserved.

Report this publication

Statistics

Seen <100 times