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Prospective evaluation of metabolic bone disease after jejunoileal bypass.

Authors
  • Sellin, J H
  • Meredith, S C
  • Kelly, S
  • Schneir, H
  • Rosenberg, I H
Type
Published Article
Journal
Gastroenterology
Publisher
Elsevier
Publication Date
Jul 01, 1984
Volume
87
Issue
1
Pages
123–129
Identifiers
PMID: 6724254
Source
Medline
License
Unknown

Abstract

Twenty-eight patients undergoing jejunoileal bypass for morbid obesity were studied prospectively for alterations in mineral metabolism and the development of metabolic bone disease. Eleven additional patients were examined for long-term complications. Serum 25-hydroxyvitamin D and fractional calcium absorption were depressed during the first 2 yr after bypass but normalized after this period. Serum parathormone remained normal. Mild osteomalacia was identified in 12% of subjects by histomorphometric analysis of undecalcified biopsy specimens. Osteomalacia was asymptomatic and could not be reliably diagnosed by noninvasive tests. Repeat biopsies demonstrated histologic improvement in 2 individuals followed serially. Improvement was not clearly related to vitamin D therapy. Abnormalities in mineral appositional rates and mineral maturation were identified in several additional patients. Studies in the long-term group did not indicate inexorable progression of metabolic bone disease. Although intestinal bypass produced several abnormalities in mineral metabolism during the first 2 yr after surgery, a trend toward normalization was evident after the period, possibly related to adaptive responses in the intestine.

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