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A prospective case–control pilot study to evaluate bone microarchitecture in children and teenagers on long-term parenteral nutrition using HR-pQCT

Authors
  • Louazon, Typhaine1, 2
  • Poinsot, Pierre1
  • Restier, Lioara1
  • Belmalih, Abdelouahed1
  • Loras-Duclaux, Irène1
  • Marotte, Stéphanie1
  • Heissat, Sophie1
  • Barnoud, Didier3
  • Chambrier, Cécile3
  • Confavreux, Cyrille B.4, 5
  • Lachaux, Alain1, 2, 6
  • Bacchetta, Justine2, 5, 7
  • Peretti, Noel1, 2, 6
  • 1 Hôpital Femme Mere Enfant HFME, 59 Bd Pinel, Bron, 69677, France , Bron (France)
  • 2 Univ Lyon, UCBL 1, Lyon, France , Lyon (France)
  • 3 Centre Hospitalier Lyon Sud, 165 chemin du Grand Revoyet, Pierre-Bénite, 69495, France , Pierre-Bénite (France)
  • 4 Centre Hospitalier Lyon Sud, Pierre Bénite, Lyon, 69495, France , Pierre Bénite, Lyon (France)
  • 5 LYOS, Lyon, France , Lyon (France)
  • 6 Univ-Lyon, Oullins, 69600, France , Oullins (France)
  • 7 Hôpital Femme Mère Enfant HFME, Bron, 69677, France , Bron (France)
Type
Published Article
Journal
Scientific Reports
Publisher
Springer Nature
Publication Date
Apr 28, 2021
Volume
11
Issue
1
Identifiers
DOI: 10.1038/s41598-021-88366-6
Source
Springer Nature
License
Green

Abstract

Long-term parenteral nutrition (PN) may induce bone complications. Tridimensional bone imaging techniques such as high-resolution peripheral quantitative computed tomography (HR-pQCT) allow the assessment of both compartmental volumetric densities and microarchitecture. Our aim was to evaluate these parameters in children and teenagers receiving long-term PN. This cross-sectional, case–control study included children older than 9 years undergoing PN for at least 2 years. They were age-, gender- and puberty-matched with healthy controls (1:2). Evaluation included biological assessment of bone metabolism (serum calcium, phosphate, and albumin; urinary calcium and creatinine; 25-OH vitamin D, osteocalcin and PTH), dual X-ray absorptiometry (DXA) and HR-pQCT at the ultradistal tibia and radius. Results are presented as median [range]. Eleven patients (3 girls) with a median age of 16 [9–19] years were included. Bone parameters assessed by HR-pQCT at the ultradistal radius and tibia were similar in patients and controls. Parathyroid hormone (PTH) levels were higher (14 [7–115] vs 16 [12–27]) and osteocalcin levels were lower (44 [15–65] vs 65 [38–142]) in patients than in controls, although within the normal range. Conclusions: there were no differences for compartmental bone densities and microarchitecture in patients undergoing chronic PN. Further longitudinal studies are required to confirm these quite reassuring preliminary results.

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