Affordable Access

Access to the full text

A prospective case–control pilot study to evaluate bone microarchitecture in children and teenagers on long-term parenteral nutrition using HR-pQCT

  • Louazon, Typhaine1, 2
  • Poinsot, Pierre1
  • Restier, Lioara1
  • Belmalih, Abdelouahed1
  • Loras-Duclaux, Irène1
  • Marotte, Stéphanie1
  • Heissat, Sophie1
  • Barnoud, Didier3
  • Chambrier, Cécile3
  • Confavreux, Cyrille B.4, 5
  • Lachaux, Alain1, 2, 6
  • Bacchetta, Justine2, 5, 7
  • Peretti, Noel1, 2, 6
  • 1 Hôpital Femme Mere Enfant HFME, 59 Bd Pinel, Bron, 69677, France , Bron (France)
  • 2 Univ Lyon, UCBL 1, Lyon, France , Lyon (France)
  • 3 Centre Hospitalier Lyon Sud, 165 chemin du Grand Revoyet, Pierre-Bénite, 69495, France , Pierre-Bénite (France)
  • 4 Centre Hospitalier Lyon Sud, Pierre Bénite, Lyon, 69495, France , Pierre Bénite, Lyon (France)
  • 5 LYOS, Lyon, France , Lyon (France)
  • 6 Univ-Lyon, Oullins, 69600, France , Oullins (France)
  • 7 Hôpital Femme Mère Enfant HFME, Bron, 69677, France , Bron (France)
Published Article
Scientific Reports
Springer Nature
Publication Date
Apr 28, 2021
DOI: 10.1038/s41598-021-88366-6
Springer Nature


Long-term parenteral nutrition (PN) may induce bone complications. Tridimensional bone imaging techniques such as high-resolution peripheral quantitative computed tomography (HR-pQCT) allow the assessment of both compartmental volumetric densities and microarchitecture. Our aim was to evaluate these parameters in children and teenagers receiving long-term PN. This cross-sectional, case–control study included children older than 9 years undergoing PN for at least 2 years. They were age-, gender- and puberty-matched with healthy controls (1:2). Evaluation included biological assessment of bone metabolism (serum calcium, phosphate, and albumin; urinary calcium and creatinine; 25-OH vitamin D, osteocalcin and PTH), dual X-ray absorptiometry (DXA) and HR-pQCT at the ultradistal tibia and radius. Results are presented as median [range]. Eleven patients (3 girls) with a median age of 16 [9–19] years were included. Bone parameters assessed by HR-pQCT at the ultradistal radius and tibia were similar in patients and controls. Parathyroid hormone (PTH) levels were higher (14 [7–115] vs 16 [12–27]) and osteocalcin levels were lower (44 [15–65] vs 65 [38–142]) in patients than in controls, although within the normal range. Conclusions: there were no differences for compartmental bone densities and microarchitecture in patients undergoing chronic PN. Further longitudinal studies are required to confirm these quite reassuring preliminary results.

Report this publication


Seen <100 times