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Proprotein convertases: Key players in inflammation-related malignancies and metastasis

Authors
  • Siegfried, Geraldine1, 2
  • Descarpentrie, Jean1, 2
  • Evrard, Serge1, 3
  • Khatib, Abdel-Majid1, 2
  • 1 Univ. Bordeaux, 33000, Bordeaux, France
  • 2 INSERM UMR1029, 33400, Pessac, France
  • 3 Institut Bergonié, 33076, Bordeaux, France
Type
Published Article
Journal
Cancer letters
Publication Date
Dec 30, 2019
Volume
473
Pages
50–61
Identifiers
DOI: 10.1016/j.canlet.2019.12.027
PMID: 31899298
PMCID: PMC7115805
Source
PubMed Central
Keywords
License
Unknown

Abstract

• Proteins maturation by the proprotein convertases plays important role in inflammation-related cancer and metastasis. • Protein precursors require the proprotein convertases for the induction of inflammation. • Understanding of the molecular mechanism linking the proprotein convertases to inflammation will allow novel therapies. • Inhibitors of the proprotein convertases constitute great potential for cancer treatment.

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