Today, the most widely employed “solution” after radical cystectomy is bladder substitution through the creation of an orthotopic neobladder. Many kind of orthotopic neobladders have been proposed and employed and, during the last 20 years, we have observed a continuous improvement of such techniques. Nevertheless, notwithstanding these technical improvements, patients with orthotopic neobladder can still report many various complications. Thus, a specific “functional” follow-up is mandatory; “functional” follow-up should be associated and integrated to oncological follow-up that these patients usually undergo. Functional follow-up should be lifelong.