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The prophylactic use of polyvinylpyridine-N-oxide (PVNO) in baboons exposed to quartz dust.

Authors
  • Goldstein, B
  • Rendall, R E
Type
Published Article
Journal
Environmental research
Publication Date
Apr 01, 1987
Volume
42
Issue
2
Pages
469–481
Identifiers
PMID: 3032603
Source
Medline
License
Unknown

Abstract

Twelve baboons were exposed to a quartz dust cloud. Four of these were also given polyvinylpyridine-N-oxide (PVNO) by aerosol and four received PVNO by aerosol and injection. A prophylactic effect was demonstrated during the course of treatment, but when treatment stopped the silicosis progressed to the same degree of severity as in the untreated animals.

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