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Prophylactic enlargement of the thecal sac volume by spinal expansion duroplasty in patients with unresectable malignant intramedullary tumors and metastases prior to radiotherapy.

Authors
  • Fiss, Ingo1
  • Bettag, C2
  • Schatlo, B2
  • von Eckardstein, K2
  • Tsogkas, I3
  • Schwarz, A3
  • von der Brelie, C2
  • Rohde, V2
  • 1 Department of Neurosurgery, Medical Center, Georg August University of Göttingen, Göttingen, Germany. [email protected] , (Germany)
  • 2 Department of Neurosurgery, Medical Center, Georg August University of Göttingen, Göttingen, Germany. , (Germany)
  • 3 Department of Neuroradiology, Medical Center, Georg August University of Göttingen, Göttingen, Germany. , (Germany)
Type
Published Article
Journal
Neurosurgical review
Publication Date
Feb 01, 2020
Volume
43
Issue
1
Pages
273–279
Identifiers
DOI: 10.1007/s10143-018-1051-0
PMID: 30426355
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Unresectable malignant intramedullary tumors and metastases usually require radiotherapy which intensifies spinal cord edema and might result in neurological decline. Spinal expansion duroplasty before radiotherapy enlarges the intrathecal volume and might thus prevent neurological deficits. The study aims to evaluate the clinical course of patients undergoing expansion duroplasty. This retrospective analysis (2007-2016) included all patients with unresectable intramedullary tumors who underwent spinal expansion duroplasty. To assess the degree of preoperative cord enlargement, we calculated the "diameter ratio": diameter of the spinal cord below and above the tumor / diameter of the tumor × 2. The presence of perimedullary cerebrospinal fluid (CSF) at the affected levels was analyzed on the preoperative magnetic resonance imaging (MRI). We recorded the occurrence of neurological deficits, wound breakdown, and CSF fistula. We screened 985 patients, 11 of which were included. Eight patients had an intramedullary metastasis, three patients a spinal malignant glioma. A diameter ratio ≤ 0.8 representing a significant preoperative intramedullary enlargement was seen in 10 cases (90.9%). Postoperative imaging was available in 9 patients, demonstrating successful decompression in 8 of the 9 patients (88.9%). The postoperative course was uneventful in 9 patients (81.8%). Mean overall survival was 13.4 (SD 16.2) months. Spinal expansion duroplasty prior to radiotherapy is a previously undescribed concept. Despite neoadjuvant radiation, no wound breakdown or CSF fistula occurred. In unresectable intramedullary tumors and metastases, spinal expansion duroplasty seems to be a safe procedure with the potential to prevent neurological decline due to radiation-induced cord swelling.

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