A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity.

Xin Wang; Xiaochen Yin; Boya Zhang; Chenfeng Liu; Yahua Lin; Xiaofen Huang; Yufang Li; Chenguang Shen; Weibin Zheng; Guofeng Fu; Junyu Chen; Yanling Wen; Wei Zhang; Bo-Sheng Pan; Mujin Fang; Zizheng Zheng; Zheng Zhang; Quan Yuan; Guo Fu; Shaowei Li; Jun Zhang; Yixin Chen; Ningshao Xia; Qinjian Zhao

doi:10.1080/22221751.2022.2050951

Publisher Website

A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity.

Authors

Wang, Xin^{1, 2}
Yin, Xiaochen¹
Zhang, Boya¹
Liu, Chenfeng³
Lin, Yahua¹
Huang, Xiaofen¹
Li, Yufang¹
Shen, Chenguang¹
Zheng, Weibin⁴
Fu, Guofeng⁴
Chen, Junyu¹
Wen, Yanling²
Zhang, Wei¹
Pan, Bo-Sheng⁵
Fang, Mujin¹
Zheng, Zizheng¹
Zhang, Zheng²
Yuan, Quan¹
Fu, Guo⁴
Li, Shaowei¹
Zhang, Jun¹
Chen, Yixin¹
Xia, Ningshao¹
Zhao, Qinjian^{1, 6}

And 4 more

¹ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, People's Republic of China. , (China)
² Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, People's Republic of China. , (China)
³ Department of Cell Biology, School of Life Science, Anhui Medical University, Hefei, People's Republic of China. , (China)
⁴ School of Life Science, Xiamen University, Xiamen, People's Republic of China. , (China)
⁵ Reverie Labs, Cambridge, MA, USA.
⁶ College of Pharmacy, Chongqing Medical University, Chongqing, People's Republic of China. , (China)

Type

Published Article

Journal

Emerging microbes & infections

Publication Date

Dec 01, 2022

Volume

11

Issue

1

Pages

914–925

Identifiers

DOI: 10.1080/22221751.2022.2050951

PMID: 35254215

Source

Medline

Keywords

Language

English

License

Unknown

Abstract

Infection caused by respiratory viruses can lead to a severe respiratory disease and even death. Vaccination is the most effective way to prevent the disease, but it cannot be quickly applied when facing an emerging infectious disease. Here, we demonstrated that immunization with an aluminium-zinc hybrid particulate adjuvant (FH-001) alone, bearing great resemblance in morphology with commonly used aluminium-based adjuvants in vaccines, could quickly induce mice to generate a broadly protective immune response to resist the lethal challenge of influenza B viruses. Furthermore, a multi-omics-based analysis revealed that the alveolar macrophage and type I interferon pathway, rather than adaptive immunity and type II interferon pathway, were essential for the observed prophylactic effect of FH-001. More importantly, a similar protective effect was observed against influenza A virus strain A/Shanghai/02/2013(H7N9), A/California/04/2009(H1N1) and respiratory syncytial virus. Therefore, we introduced here a new and promising strategy that can be quickly applied during the outbreak of emerging respiratory viruses.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 04/06/2022 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/35254215

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