Affordable Access

deepdyve-link
Publisher Website

A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity.

Authors
  • Wang, Xin1, 2
  • Yin, Xiaochen1
  • Zhang, Boya1
  • Liu, Chenfeng3
  • Lin, Yahua1
  • Huang, Xiaofen1
  • Li, Yufang1
  • Shen, Chenguang1
  • Zheng, Weibin4
  • Fu, Guofeng4
  • Chen, Junyu1
  • Wen, Yanling2
  • Zhang, Wei1
  • Pan, Bo-Sheng5
  • Fang, Mujin1
  • Zheng, Zizheng1
  • Zhang, Zheng2
  • Yuan, Quan1
  • Fu, Guo4
  • Li, Shaowei1
  • And 4 more
  • 1 State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, People's Republic of China. , (China)
  • 2 Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, People's Republic of China. , (China)
  • 3 Department of Cell Biology, School of Life Science, Anhui Medical University, Hefei, People's Republic of China. , (China)
  • 4 School of Life Science, Xiamen University, Xiamen, People's Republic of China. , (China)
  • 5 Reverie Labs, Cambridge, MA, USA.
  • 6 College of Pharmacy, Chongqing Medical University, Chongqing, People's Republic of China. , (China)
Type
Published Article
Journal
Emerging microbes & infections
Publication Date
Dec 01, 2022
Volume
11
Issue
1
Pages
914–925
Identifiers
DOI: 10.1080/22221751.2022.2050951
PMID: 35254215
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Infection caused by respiratory viruses can lead to a severe respiratory disease and even death. Vaccination is the most effective way to prevent the disease, but it cannot be quickly applied when facing an emerging infectious disease. Here, we demonstrated that immunization with an aluminium-zinc hybrid particulate adjuvant (FH-001) alone, bearing great resemblance in morphology with commonly used aluminium-based adjuvants in vaccines, could quickly induce mice to generate a broadly protective immune response to resist the lethal challenge of influenza B viruses. Furthermore, a multi-omics-based analysis revealed that the alveolar macrophage and type I interferon pathway, rather than adaptive immunity and type II interferon pathway, were essential for the observed prophylactic effect of FH-001. More importantly, a similar protective effect was observed against influenza A virus strain A/Shanghai/02/2013(H7N9), A/California/04/2009(H1N1) and respiratory syncytial virus. Therefore, we introduced here a new and promising strategy that can be quickly applied during the outbreak of emerging respiratory viruses.

Report this publication

Statistics

Seen <100 times