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Prophylactic anti-D preparations display variable decreases in Fc-fucosylation of anti-D.

Authors
  • Kapur, Rick
  • Della Valle, Luciana
  • Verhagen, Onno J H M
  • Hipgrave Ederveen, Agnes
  • Ligthart, Peter
  • de Haas, Masja
  • Kumpel, Belinda
  • Wuhrer, Manfred
  • van der Schoot, C Ellen
  • Vidarsson, Gestur
Type
Published Article
Journal
Transfusion
Publication Date
Mar 01, 2015
Volume
55
Issue
3
Pages
553–562
Identifiers
DOI: 10.1111/trf.12880
PMID: 25234110
Source
Medline
License
Unknown

Abstract

RhIG preparations vary in Fc-fucosylation and all demonstrate increased galactosylation. Despite not knowing the exact working mechanism, immunoprophylaxis could perhaps be optimized by selection of donors whose anti-D have low amounts of Fc-fucose, to increase the clearance activity of anti-D preparations, as well as high amounts of galactosylation, for anti-inflammatory effects. Implementing a biologic assay in the standardization of RhIG preparations might be considered.

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