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Properties of the Langmuir and Langmuir–Blodgett monolayers of cholesterol-cyclosporine A on water and polymer support

Authors
  • Przykaza, K.1
  • Woźniak, K.1
  • Jurak, M.1
  • Wiącek, A. E.1
  • Mroczka, R.2
  • 1 University of Maria Curie-Skłodowska, Department of Physical Chemistry-Interfacial Phenomena, Faculty of Chemistry, Maria Curie-Skłodowska Sq. 3, Lublin, 20-031, Poland , Lublin (Poland)
  • 2 The John Paul II Catholic University of Lublin, Laboratory of X-ray Optics, Centre for Interdisciplinary Research, Konstantynów 1J, Lublin, 20-708, Poland , Lublin (Poland)
Type
Published Article
Journal
Adsorption
Publisher
Springer US
Publication Date
May 27, 2019
Volume
25
Issue
4
Pages
923–936
Identifiers
DOI: 10.1007/s10450-019-00117-2
Source
Springer Nature
Keywords
License
Green

Abstract

The paper deals with the cholesterol–cyclosporine A (Chol–CsA) monolayers at the air/water interface investigated using the Langmuir trough coupled with the Brewster’s angle microscopy. The compressed films were transferred onto the PEEK polymer support by means of the Langmuir–Blodgett technique. To improve molecules adhesion and organization the PEEK surface was treated with air plasma before thin films deposition. The obtained surfaces were characterized by means of atomic force microscope (AFM). Then, the wettability of the supported monolayers was determined by the contact angle measurements. Finally, the surface free energy and its components were evaluated from the theoretical approach proposed by van Oss et al. The obtained results reveal correlation between properties of the Langmuir monolayers at the air/water interface and those of the Langmuir–Blodgett films on PEEK. This was found to be helpful for understanding the wettability of organized molecular films on the polymer support as far as biocompatibility improve is concerned. The preparation of films with defined polarity and various compositions is an important step in the development of polymer surfaces with increased biofunctionality. It is believed that the results presented in this paper can be exploited in the in vivo studies.

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