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Propagation of Rat Parvovirus in Thymic Lymphoma Cell Line C58(NT)D and Subsequent Appearance of a Resistant Cell Clone after Lytic Infection

Authors
  • Yutaka Ueno
  • Tanenobu Harada
  • Hiroyoshi Iseki
  • Takayuki Ohshima
  • Fumihiro Sugiyama
  • Ken-ichi Yagami
Publisher
American Society for Microbiology
Publication Date
Apr 01, 2001
Source
PMC
Keywords
License
Unknown

Abstract

Rat parvovirus (RPV) is nonpathogenic in rats but causes persistent lymphocytotropic infection. We found that RPV was propagated in rat thymic lymphoma cell line C58(NT)D and induced apoptosis. Interestingly, a resistant subclone, C58(NT)D/R, from surviving cells after lytic infection had differentiated phenotypic modifications, such as increased cell adherence, resistance to apoptosis, and suppressed tumorigenicity.

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