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Promoting athero-protective immunity by vaccination with low density lipoprotein-derived antigens.

Authors
  • Nilsson, Jan1
  • Shah, Prediman K2
  • 1 Department of Clinical Sciences Malmö, Lund University, Sweden. Electronic address: [email protected] , (Sweden)
  • 2 Oppenheimer Atherosclerosis Research Center, Department of Cardiology and Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA, 90048, USA.
Type
Published Article
Journal
Atherosclerosis
Publication Date
Aug 25, 2021
Identifiers
DOI: 10.1016/j.atherosclerosis.2021.08.033
PMID: 34462127
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Immune responses activated by LDL particles that have been trapped and oxidized in the arterial wall play an important role in atherosclerosis. Some of these immune responses are protective by facilitating the removal of pro-inflammatory and toxic lipid species formed as result of LDL oxidation. However, should these protective immune responses be insufficient, other more potent pro-inflammatory immune responses instead contributing to disease progression will gradually become dominant. The importance of the balance between protective and pathogenic immunity is particularly apparent when it comes to the adaptive immune system where pro-inflammatory T helper 1 (Th1) type T cells aggravate atherosclerosis, while regulatory T cells (Tregs) have an opposing role. As oxidized LDL is a key autoantigen in atherosclerosis, it has become an interesting possibility that immune-modulatory therapy that favors the activity of apolipoprotein B peptide-specific Tregs could be developed into a novel treatment strategy for prevention/stabilization of atherosclerosis and ischemic cardiovascular events. Indeed, several such oxidized LDL tolerance vaccines have shown promising results in animal models of atherosclerosis. This review will discuss the experimental background for development of atherosclerosis vaccines based on LDL-derived antigens as well as the challenges involved in translating these findings into clinical application. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

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