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Promoting Adherence to Iron Chelation Treatment in Beta-Thalassemia Patients

Authors
  • Eziefula, Chinea
  • Shah, Farrukh T
  • Anie, Kofi A
Type
Published Article
Journal
Patient Preference and Adherence
Publisher
Dove Medical Press
Publication Date
Jun 07, 2022
Volume
16
Pages
1423–1437
Identifiers
DOI: 10.2147/PPA.S269352
PMID: 35698633
PMCID: PMC9188463
Source
PubMed Central
Keywords
Disciplines
  • Review
License
Unknown

Abstract

Thalassaemia is one of the commonest inherited genetic disorders world-wide with around 25,000 births of the most severely affected transfusion dependent children annually. Patients with transfusion dependent thalassaemia require regular blood transfusions to maintain life but because of this will develop iron overload. To remove the excess iron, patients are required to take iron chelation therapy (ICT). ICT requires lifelong adherence to treatment to prevent end organ damage from developing. Many of these preventable complications make adherence to therapy more complex for patients. In this review, we focus on two commonly encountered patient scenarios and discuss how different psychological models and a relational theory can be used to understand and support adherence to treatment.

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