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Promoter methylation correlates with reduced Smad4 expression in advanced prostate cancer.

Authors
  • Aitchison, Alan A
  • Veerakumarasivam, Abhi
  • Vias, Maria
  • Kumar, Rajeev
  • Hamdy, Freddie C
  • Neal, David E
  • Mills, Ian G
Type
Published Article
Journal
The Prostate
Publication Date
May 01, 2008
Volume
68
Issue
6
Pages
661–674
Identifiers
DOI: 10.1002/pros.20730
PMID: 18213629
Source
Medline
License
Unknown

Abstract

This indicates that epigenetic changes affect the expression of the Smad4 protein in prostate cancer and points to methylation of the promoter as a novel marker of and contributor to the disease warranting further study.

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