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Promising treatment strategies to combat Staphylococcus aureus biofilm infections: an updated review.

Authors
  • Seethalakshmi, P S1
  • Rajeev, Riya1
  • Kiran, George Seghal2
  • Selvin, Joseph1
  • 1 Department of Microbiology, Pondicherry University, Puducherry, India. , (India)
  • 2 Department of Food Science and Technology, Pondicherry University, Puducherry, India. , (India)
Type
Published Article
Journal
Biofouling
Publisher
Informa UK (Taylor & Francis)
Publication Date
Nov 01, 2020
Volume
36
Issue
10
Pages
1159–1181
Identifiers
DOI: 10.1080/08927014.2020.1857743
PMID: 33353409
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Staphylococcus aureus is a leading cause of nosocomial and community-acquired infections. The formation of biofilm by this pathogen renders it resilient to antimicrobial agents, which complicates the treatment of such infections. S. aureus can form biofilms with other pathogens and cause polymicrobial infections recalcitrant to antimicrobial agents. Therefore, anti-biofilm agents against which this bacterium cannot develop resistance are a highly desirable treatment strategy. Nanoparticles and some non-antimicrobial drugs proposed for various clinical purposes have proven to be excellent antibacterial and anti-biofilm agents to control S. aureus biofilm infections. A variety of chemically distinct compounds capable of acting as anti-biofilm agents against S. aureus have been extracted from microbial sources. This review explains the characteristics of S. aureus biofilms, emphasizing the therapeutic potential of nanoparticles, repurposed drugs, and anti-biofilm agents from microbial sources to combat S. aureus biofilm infections.

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