Affordable Access

Publisher Website

Prolonged generation of multi-lineage blood cells in wild-type animals from pluripotent stem cells

Authors
  • Peng, Huan
  • Lin, Yunqing
  • Hu, Fangxiao
  • Lv, Cui
  • Wu, Bingyan
  • Weng, Qitong
  • Liu, Lijuan
  • Xia, Chengxiang
  • Liu, Xiaofei
  • Zhao, Yalan
  • Zhang, Qi
  • Geng, Yang
  • Zhang, Mengyun
  • Wang, Jinyong
Type
Published Article
Journal
Stem Cell Reports
Publisher
Elsevier
Publication Date
Feb 16, 2023
Volume
18
Issue
3
Pages
720–735
Identifiers
DOI: 10.1016/j.stemcr.2023.01.009
PMID: 36801005
PMCID: PMC10031304
Source
PubMed Central
Disciplines
  • Article
License
Unknown

Abstract

In this article, Wang and colleagues show that combinational expression of exogenous Runx1 , Hoxa9 , and Hoxa10 guides mESC differentiation toward hematopoietic progenitors, transplantation of which reliably reconstitutes prolonged multiple blood cells, including myeloid cells, B cells, and T cells in wild-type animals. The study provides insights into reconstituting generative hematopoiesis using a PSC source.

Report this publication

Statistics

Seen <100 times