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Proliferation of endocrine (APUD-type) cells during early N-diethylnitrosamine-induced lung carcinogenesis in hamsters.

Authors
  • Reznik-Schüller, H
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
May 01, 1976
Volume
1
Issue
5
Pages
255–258
Identifiers
PMID: 1016952
Source
Medline
License
Unknown

Abstract

Pronounced proliferation of amine precursor uptake and decarboxylase activity (APUD-type) cells was found in the segmental bronchi and bronchioles of Syrian golden hamsters during N-diethylnitrosamine (DEN)-induced lung carcinogenesis. Since similar epithelial alterations did not occur in previous experiments after benzo(a)pyrene (B(a)P) treatment, it is concluded that the initial stages of lung carcinogenesis differ with respect to the carcinogen administered.

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