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Prolactin signaling and Stat5: going their own separate ways?

Authors
  • Brisken, Cathrin
  • Ayyanan, Ayyakkannu
  • Doppler, Wolfgang
Type
Published Article
Journal
Breast Cancer Research
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 01, 2002
Volume
4
Issue
6
Pages
209–212
Identifiers
PMID: 12473164
Source
Medline
License
Unknown

Abstract

Miyoshi et al. compared the role of the prolactin receptor (PrlR) and its downstream mediator, the signal transducer and activator of transcription 5 (Stat5), in mammary epithelial cells in vivo by studying PrlR-/- and Stat5ab-/- mouse mammary epithelial transplants during pregnancy. At first glance, the two mutant epithelia appear to have similar defects in the differentiation of the alveolar epithelium. However, a closer examination by Miyoshi et al. revealed defects in the epithelial architecture of the smallest ducts of Stat5ab-/- transplants not apparent in the PrlR-/- transplants, suggesting that Stat5 is more than a simple mediator of PrlR action.

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