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Progressive genetic alterations of adenoid cystic carcinoma with high-grade transformation.

Authors
  • 1
  • 1 Department of Pathology and Laboratory Medicine, University of Pittsburgh, 200 Lothrop St., Pittsburgh, PA 15213, USA. [email protected]
Type
Published Article
Journal
Archives of Pathology & Laboratory Medicine
1543-2165
Publisher
Archives of Pathology and Laboratory Medicine
Publication Date
Volume
135
Issue
1
Pages
123–130
Identifiers
DOI: 10.1043/2010-0048-OAR.1
PMID: 21204718
Source
Medline
License
Unknown

Abstract

High-grade transformation in adenoid cystic carcinoma is a complex process that is reflected by several chromosomal alterations. Our findings implicate C-MYC amplification in this progression, although the role of HER2/neu is still unclear. Other candidate oncogenes, particularly on chromosome 17q23, warrant investigation in this rare tumor.

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