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Progress of research on the immune tolerance of chronic HBV infection

Authors
  • Li, Xuemei
  • Li, Xiaoxia
Type
Published Article
Journal
Infection International
Publisher
Sciendo
Publication Date
Sep 30, 2018
Volume
7
Issue
3
Pages
88–93
Identifiers
DOI: 10.2478/ii-2018-0026
Source
De Gruyter
Keywords
License
Green

Abstract

Immune tolerance is a specific lack or negative response of T and B lymphocytes to antigen. According to different formation periods, immune tolerance can be divided into central and peripheral tolerances. The immune tolerance of the body to hepatitis B virus (HBV) after infection is the main cause of chronic HBV infection. In this paper, the functional defects of hepatitis B virus e antigen and dendritic cells, hyporesponsiveness of cytotoxic T lymphocyte, variation of helper T lymphocytes and cytokines, HBV genotype and genome, and the role of host gene polymorphism in the formation of immune tolerance in chronic HBV infection and its related research progress are introduced briefly.

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