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[Progress in research of chitosan as a non-viral gene delivery vector].

Authors
Type
Published Article
Journal
Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji
Publication Date
Volume
28
Issue
10
Pages
1321–1324
Identifiers
PMID: 17035195
Source
Medline

Abstract

Efficiency of non-viral gene delivery based on chitosan and chitosan derivatives as DNA condensing carrier is dependent on a series of factors, such as complex size, the charge ratio of chitosan/DNA, molecular mass of chitosan, the degree of chitosan deacetylation, pH and serum concentration of the transfection medium. Through modifying the chitosan in a certain extent, we can change the efficiency of transfection. Studies on transfection condition, efficiency and mechanism using chitosan and chitosan derivatives as transfection agents are reviewed.

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