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Progress in investigating the relationship between Schlafen5 genes and malignant tumors

Authors
  • Tu, Teng1
  • Yuan, Ye2
  • Liu, Xiaoxue1
  • Liang, Xin2
  • Yang, Xiaofan3
  • Yang, Yue1
  • 1 School of Basic Medicine, Mudanjiang Medical College, Mudanjiang, Heilongjiang , (China)
  • 2 Beidahuang Industry Group General Hospital, Harbin , (China)
  • 3 The 1st Clinical Medical College, Mudanjiang Medical College, Mudanjiang, Heilongjiang , (China)
Type
Published Article
Journal
Frontiers in Oncology
Publisher
Frontiers Media SA
Publication Date
Sep 11, 2023
Volume
13
Identifiers
DOI: 10.3389/fonc.2023.1248825
Source
Frontiers
Keywords
Disciplines
  • Oncology
  • Review
License
Green

Abstract

The Schlafen5(SLFN5)gene belongs to the third group of the Schlafen protein family. As a tumor suppressor gene, SLFN5 plays a pivotal role in inhibiting tumor growth, orchestrating cell cycle regulation, and modulating the extent of cancer cell infiltration and metastasis in various malignancies. However, the high expression of SLFN 5 in some tumors was positively correlated with lymph node metastasis, tumor stage, and tumor grade. This article endeavors to elucidate the reciprocal relationship between the SLFN5 gene and malignant tumors, thereby enhancing our comprehension of the intricate mechanisms underlying the SLFN5 gene and its implications for the progression, invasive potential, and metastatic behavior of malignant tumors. At the same time, this paper summarizes the basis of SLFN 5 as a new biomarker of tumor diagnosis and prognosis, and provides new ideas for the target treatment of tumor.

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