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Progress and Challenges in the Prevention, Diagnosis, and Management of Cytomegalovirus Infection in Transplantation.

Authors
  • Limaye, Ajit P1
  • Babu, Tara M2, 3
  • Boeckh, Michael4, 5
  • 1 Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA [email protected]
  • 2 Division of Infectious Diseases, University of Rochester Medical Center, Rochester, New York, USA.
  • 3 Department of Infectious Diseases, Overlake Medical Center, Bellevue, Washington, USA.
  • 4 Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.
  • 5 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Type
Published Article
Journal
Clinical Microbiology Reviews
Publisher
American Society for Microbiology
Publication Date
Dec 16, 2020
Volume
34
Issue
1
Identifiers
DOI: 10.1128/CMR.00043-19
PMID: 33115722
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Hosts with compromised or naive immune systems, such as individuals living with HIV/AIDS, transplant recipients, and fetuses, are at the highest risk for complications from cytomegalovirus (CMV) infection. Despite substantial progress in prevention, diagnostics, and treatment, CMV continues to negatively impact both solid-organ transplant (SOT) and hematologic cell transplant (HCT) recipients. In this article, we summarize important developments in the field over the past 10 years and highlight new approaches and remaining challenges to the optimal control of CMV infection and disease in transplant settings. Copyright © 2020 American Society for Microbiology.

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