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Programmed syndrome of hypernatremic hypertension in ovine twin lambs.

Authors
Type
Published Article
Journal
American Journal of Obstetrics and Gynecology
0002-9378
Publisher
Elsevier
Publication Date
Volume
192
Issue
4
Pages
1196–1204
Identifiers
PMID: 15846202
Source
Medline

Abstract

These results indicate that ovine twin gestation and nursing markedly reduced body weight at 21 days of age, with evidence of plasma hypernatremia, hypertension, and reduced glomerular filtration rates, which persisted throughout hypotonic saline solution infusion. Consistent with epidemiologic studies of humans, these results demonstrate that gestational/newborn nutrient stress may program hypertension in offspring.

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