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Prognostic Value of C-Reactive Protein in Patients With Coronavirus 2019.

Authors
  • Luo, Xiaomin1
  • Zhou, Wei2
  • Yan, Xiaojie1
  • Guo, Tangxi1
  • Wang, Benchao1
  • Xia, Hongxia1
  • Ye, Lu1
  • Xiong, Jun1
  • Jiang, Zongping1
  • Liu, Yu1
  • Zhang, Bicheng2
  • Yang, Weize1
  • 1 Department of Emergency, Eastern Campus, Renmin Hospital of Wuhan University, Wuhan, China. , (China)
  • 2 Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China. , (China)
Type
Published Article
Journal
Clinical Infectious Diseases
Publisher
Oxford University Press
Publication Date
Nov 19, 2020
Volume
71
Issue
16
Pages
2174–2179
Identifiers
DOI: 10.1093/cid/ciaa641
PMID: 32445579
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

An elevated serum C-reactive protein (CRP) level was observed in most patients with coronavirus disease 2019 (COVID-19). Data for COVID-19 patients with clinical outcome in a designated hospital in Wuhan, China, were retrospectively collected and analyzed from 30 January 2020 to 20 February 2020. The prognostic value of admission CRP was evaluated in patients with COVID-19. Of 298 patients enrolled, 84 died and 214 recovered. Most nonsurvivors were male, older, or with chronic diseases. Compared with survivors, nonsurvivors showed significantly elevated white blood cell and neutrophil counts, neutrophil to lymphocyte ratio (NLR), systemic immune inflammation index (defined by platelet count multiplied by NLR), CRP, procalcitonin, and D-dimer and showed decreased red blood cell, lymphocyte, and platelet counts. Age, neutrophil count, platelet count, and CRP were identified as independent predictors of adverse outcome. The area under the receiver operating characteristic (ROC) curve (AUC) of CRP (0.896) was significantly higher than that of age (0.833), neutrophil count (0.820), and platelet count (0.678) in outcome prediction (all P < .05). With a cutoff value of 41.4, CRP exhibited sensitivity of 90.5%, specificity of 77.6%, positive predictive value of 61.3%, and negative predictive value of 95.4%. CRP was also an independent discriminator of severe/critical illness on admission with an AUC (0.783) comparable to age (0.828) and neutrophil count (0.729) (both P > .05). In patients with COVID-19, admission CRP correlated with disease severity and tended to be a good predictor of adverse outcome. © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected]

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