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The prognostic significance of pdl1 and foxp3 expressions in tumor cells and the tumor microenvironment of ovarian epithelial tumors

Authors
  • Kahraman, Dudu Solakoglu1
  • Diniz, Gulden1
  • Sayhan, Sevil1
  • Sayar, Ceren1
  • Ayaz, Duygu1
  • Gokcu, Mehmet2
  • Karadeniz, Tugba1
  • 1 Department of Pathology, Izmir Tepecik Education and Research Hospital, Turkey
  • 2 Department of Gynecological Oncology Clinics, Izmir Tepecik Education and Research Hospital, Turkey
Type
Published Article
Journal
International journal of clinical and experimental pathology
Publication Date
Aug 01, 2018
Volume
11
Issue
8
Pages
3884–3890
Identifiers
PMID: 31949776
PMCID: PMC6962806
Source
PubMed Central
Keywords
License
Unknown

Abstract

Background: The aim of this study is to determine the prognostic values of PDL1 expression in ovarian epithelial tumors and to detect the presence of FOXP3-positive T reg cells in the tumor microenvironment. Methods: This study included patients with benign, borderline or malignant ovarian serous tumors (n=82), mucinous cancer (n=17) and endometrioid cancer (n=36). FOXP3 and PDL1 were immunohistochemically evaluated and compared with histopathological and clinical prognostic parameters. Results: There was no expression of PDL1 in any tumor cell. However, PDL1-positive inflammatory cells were seen in 10 cases (7.3%) with mucinous carcinoma (n=6), endometrioid carcinoma (n=2), borderline (n=1), and benign (n=1) serous tumors. It was also determined that there was a significant positive correlation between PD-L1 expression in tumor infiltrating cells and survival (P<0.01). In 47 (34.3%) cases, there were FOXP3-positive cells. The number of FOXP3-positive cells was significantly higher in ovarian cancer, especially in serous and endometrioid carcinomas, rather than benign and borderline tumors (P=0.007). But there was no statistically significant association between the survival times and the presence of T regs (P=0.241). Conclusions: This study demonstrated that the presence of FOXP3 and PDL1-positive regulatory T cells in TILs was associated with mainly malignant tumors. We also found that the presence of PD-L1-positive inflammatory cells has a positive effect on survival.

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