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[Prognostic significance of loss of heterozygosity in breast cancer].

Authors
  • Iwase, H
  • Iwata, H
  • Toyama, T
  • Hara, Y
  • Omoto, Y
  • Kobayashi, S
Type
Published Article
Journal
Gan to kagaku ryoho. Cancer & chemotherapy
Publication Date
Apr 01, 1998
Volume
25 Suppl 3
Pages
426–430
Identifiers
PMID: 9589047
Source
Medline
License
Unknown

Abstract

Loss of heterozygosity (LOH) was analyzed in 113 cases of sporadic breast cancer using 35 microsatellite markers on 20 chromosomes. LOH was frequently seen in 17p (44%), 16q (31%), 17q (29%) and 13q (23%). Individual patients were scored according to the incidence of LOH at the above four chromosomal markers; with no LOH as 1, with one or two LOH as 2, and with three of four LOH as 3. A high LOH score was well associated with high histological grade (p = 0.019) and a significantly poor prognosis (p = 0.0035). These data suggest that accumulation of LOH occurs at a later stage of breast cancer progression, and that the LOH score may be a useful prognostic marker of breast cancer.

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