Affordable Access

deepdyve-link
Publisher Website

The prognostic significance of the aberrant extremes of p53 immunophenotypes in breast cancer.

Authors
  • Boyle, David P
  • McArt, Darragh G
  • Irwin, Gareth
  • Wilhelm-Benartzi, Charlotte S
  • Lioe, Tong F
  • Sebastian, Elena
  • McQuaid, Stephen
  • Hamilton, Peter W
  • James, Jacqueline A
  • Mullan, Paul B
  • Catherwood, Mark A
  • Harkin, D Paul
  • Salto-Tellez, Manuel
Type
Published Article
Journal
Histopathology
Publication Date
Sep 01, 2014
Volume
65
Issue
3
Pages
340–352
Identifiers
DOI: 10.1111/his.12398
PMID: 24612173
Source
Medline
Keywords
License
Unknown

Abstract

Patients with extreme p53 IHC expression have a worse OS than those with NE expression. Accounting for EN as well as EP expression improves the prognostic impact. Extreme expression positively correlates with nodal stage and histological grade, and negatively with hormone receptor status. Extreme expression may relate to specific mutational status.

Report this publication

Statistics

Seen <100 times