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Prognostic and predictive value of vascular endothelial growth factor and its soluble receptors, VEGFR-1 and VEGFR-2 levels in the sera of small cell lung cancer patients.

Authors
  • Ustuner, Zeki1
  • Saip, Pinar
  • Yasasever, Vildan
  • Vural, Burcak
  • Yazar, Aziz
  • Bal, Cengiz
  • Ozturk, Betul
  • Ozbek, Ugur
  • Topuz, Erkan
  • 1 Department of Medical Oncology, Osmangazi University Medical Faculty, Ataturk Street, Meselik, Eskisehir, 26480, Turkey. [email protected]
Type
Published Article
Journal
Medical oncology (Northwood, London, England)
Publication Date
2008
Volume
25
Issue
4
Pages
394–399
Identifiers
DOI: 10.1007/s12032-008-9052-4
PMID: 18317954
Source
Medline
License
Unknown

Abstract

Low serum VEGF concentration is a significant and independent prognostic factor in SCLC patients. Surveillance of VEGF and its receptors to predict chemotherapy response is not useful. Whether the levels of serum VEGF and its receptors VEGFR-1 and VEGFR-2 have value in detecting treatment modalities of SCLC need further studies.

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