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Prognostic factors for virological response in antiretroviral therapy-naive patients in the MONARK Trial randomized to ritonavir-boosted lopinavir alone.

Authors
  • Flandre, Philippe
  • Delaugerre, Constance
  • Ghosn, Jade
  • Chaix, Marie Laure
  • Horban, Andrzej
  • Girard, Pierre-Marie
  • Gladysz, Andrzej
  • Cohen-Codar, Isabelle
  • Van, Philippe Ngo
  • Taburet, Anne-Marie
  • Christine Rouzioux
  • Delfraissy, Jean-François
Type
Published Article
Journal
Diabetes Care
Publisher
American Diabetes Association
Publication Date
2009
Volume
14
Issue
1
Pages
93–97
Identifiers
PMID: 19320241
Source
USPC - SET - SVS
License
Unknown

Abstract

HIV-1 RNA measured at baseline or at week 4 and HIV-1 subtype (B versus non-B) were independent predictive factors of VR in patients starting therapy with LPV/r alone. Although based on a small sample size, results of this study showed that adherence to therapy is lower in patients harbouring non-B subtypes and appears to be a key factor of VR in the context of protease inhibitor monotherapy.

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