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Prognostic factors of patients with Gliomas – an analysis on 335 patients with Glioblastoma and other forms of Gliomas

Authors
  • Liang, Jianfeng1
  • Lv, Xiaomin2
  • Lu, Changyu1
  • Ye, Xun1, 3
  • Chen, Xiaolin1, 3
  • Fu, Jia1
  • Luo, Chenghua1
  • Zhao, Yuanli1, 3
  • 1 Peking University International Hospital, No.1 Science Park Road, ZGC Life Science Park, Beijing, 102206, China , Beijing (China)
  • 2 The First Hospital of Jilin University, Changchun, Jilin Province, 130021, China , Jilin Province (China)
  • 3 Capital Medical University, Beijing, 100050, China , Beijing (China)
Type
Published Article
Journal
BMC Cancer
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 15, 2020
Volume
20
Issue
1
Identifiers
DOI: 10.1186/s12885-019-6511-6
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundThe prognosis of glioma is poor, despite recent advances in diagnosis and treatment of the disease. It is important to investigate the clinical characteristics and prognostic factors of glioma so as to provide basis for treatment and management of patients.MethodA total of 335 patients with glioma were included in this study. These patients were admitted to the medical center between November 2015 and December 2018. The clinical data, including demographic data, tumor characteristics, treatment strategy, expression pattern of tumor markers, and survival data, were retrospectively reviewed. Survival data were analyzed using Kaplan-Meier curves with log-rank test, while multivariate analysis Cox regression model was used to investigate risk factors for mortality.ResultsIn this patient cohort, glioblastoma (40%), diffuse glioma (14.6%) and oligodendroglioma (9.6%) were the most common pathological types. The expression of Ki-67 was associated with several clinicopathological parameters (e.g. tumor type, grade, and number of lesions). In addition, Ki-67 correlated with the mortality within the first year of the post-treatment follow-up (P < 0.001). Kaplan-Maier analysis revealed that older patients (≥ 45 years) displayed worse prognosis than those aged under 45 years (P = 0.038). Dismal prognosis was also associated with clinical parameters, including high tumor grade, multiple lesions, and Karnofsky performance score (KPS). Multivariate analysis showed that low KPS (< 85) increased the risk of mortality by 2.3 folds with a 95% CI of 1.141 to 4.776 (P = 0.020). Low tumor grade (grade 1–2) oppositely reduced the mortality risk by 0.22 folds (95% CI, 0.065 to 0.763, P = 0.0168).ConclusionKPS and tumor grade were independent prognostic factors in patients with gliomas.

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