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[Prognosis of chronic renal failure in patients with membranous nephropathy].

Authors
  • Razukeviciene, Loreta
  • Kuzminskis, Vytautas
  • Bumblyte, Inga Arūne
  • Laurinavicius, Arvydas
Type
Published Article
Journal
Medicina (Kaunas, Lithuania)
Publication Date
Jan 01, 2003
Volume
39 Suppl 1
Pages
9–15
Identifiers
PMID: 12761414
Source
Medline
License
Unknown

Abstract

Two hundred eighty patients underwent renal biopsy during the period of 1995-1999 in five nephrological centers of Lithuania. All renal biopsies materials were examined in the State Center of Pathology. In 20 patients (7.1%) membranous nephropathy was found. The main clinical presentation at the moment of renal biopsy were nephrotic syndrome (55%) and arterial hypertension (55%). Glomerulosclerosis was found in 30% of patients, interstitial fibrosis--in 40% of patients. The results of analysis showed multiple risk factors for renal failure progression: initial renal failure (p=0.000), systolic and diastolic hypertension (p=0.009 and p=0.009), proteinuria (=1 g/l, =3 g/l) (p=0.026). Membranous nephropathy was found to have a relatively good long-term prognosis - the renal survival rate in 5 years was 84.2%. Kaplan-Meier survival analysis showed that initial renal failure was risk factor (logrank p=0.018, Breslov p=0.032) associated with development of end-stage renal disease in 5 years.

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