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Proglumide has access to brain and antagonizes the central satiety effect of cholecystokinin octapeptide in the dog.

Authors
Type
Published Article
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
417
Issue
2
Pages
355–359
Identifiers
PMID: 3651819
Source
Medline
License
Unknown

Abstract

Intra-third cerebroventricularly administered cholecystokinin octapeptide (CCK-8) decreased food intake through central mechanisms in the dog. Proglumide, administered intravenously, did enter into cerebrospinal (ventricular) fluid, and partially, but significantly, reversed this effect. CR1409, one of the newly synthesized glutaramic derivatives, blocked CCK-8-induced satiety more strongly than proglumide. These results indicate that systemic proglumide and CR1409 result in antagonism of the central CCK receptor for satiety in the dog.

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