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Progesterone receptor activation. an alternative to SERMs in breast cancer.

Authors
  • Desreux, J
  • Kebers, F
  • Noël, A
  • Francart, D
  • Van Cauwenberge, H
  • Heinen, V
  • Thomas, J L
  • Bernard, A M
  • Paris, J
  • Delansorne, R
  • Foidart, J M
Type
Published Article
Journal
European Journal of Cancer
Publisher
Elsevier
Publication Date
Sep 01, 2000
Volume
36 Suppl 4
Identifiers
PMID: 11056336
Source
Medline
License
Unknown

Abstract

Data regarding the effects of progesterone and a progestagen on human normal breast epithelial cell proliferation and apoptosis are presented here. In postmenopausal women, adding progesterone to percutaneously administrated oestradiol significantly reduces the proliferation induced by oestradiol. In vitro and in premenopausal women, stopping the administration of nomegestrol acetate triggers a peak of apoptosis. Fibro-adenoma and cancerous cells do not show this regulation of apoptosis. Progesterone seems to be important in normal breast homeostasis.

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