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Profound apoptosis-mediated regional myocyte loss and compensatory hypertrophy in pigs with hibernating myocardium.

Authors
  • Lim, H
  • Fallavollita, J A
  • Hard, R
  • Kerr, C W
  • Canty, J M Jr
Type
Published Article
Journal
Circulation
Publication Date
Dec 07, 1999
Volume
100
Issue
23
Pages
2380–2386
Identifiers
PMID: 10587344
Source
Medline
License
Unknown

Abstract

These findings indicate that reversible ischemia in an area of chronically reduced coronary flow reserve induces regional myocyte loss via an apoptotic mechanism. This may contribute to the progression of chronic coronary disease to heart failure and explain the lack of complete functional recovery after revascularization in hibernating myocardium.

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