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Productive replication of human adenoviruses in mouse epidermal cells.

Authors
  • Ganly, I
  • Mautner, V
  • Balmain, A
Type
Published Article
Journal
Journal of virology
Publication Date
Mar 01, 2000
Volume
74
Issue
6
Pages
2895–2899
Identifiers
PMID: 10684307
Source
Medline
License
Unknown

Abstract

In contrast to most cells of mouse origin, cell lines derived from mouse epidermis are permissive for replication of human adenovirus type 5. The extent of epidermal cell differentiation correlated with the level of E1A expression and virus replication. Mouse epidermal cells may provide useful models for cancer therapy using replication-competent human adenoviruses.

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