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Production of mononuclear cell factor by mononuclear phagocytes from rheumatoid synovial fluid.

Authors
Type
Published Article
Journal
The Journal of rheumatology
Publication Date
Volume
12
Issue
3
Pages
412–417
Identifiers
PMID: 3862846
Source
Medline
License
Unknown

Abstract

Collagenase-and PGE1-stimulating activities (mononuclear cell factor or MCF) have been found in culture supernatants from synovial fluid macrophages (SF-M phi) of patients wih rheumatoid arthritis. The apparent molecular weight of the MCF activity present in SF-M phi supernatants was between 15-20,000 daltons, which is similar to interleukin I. All the SF-M phi supernatants from patients tested showed the MCF activity. Our study presents evidence for MCF production by monocyte-macrophages at the local site of the lesion.

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