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Production of high specific activity 123I for protein iodination for medical use.

Authors
  • Legoux, Y
  • Cieur, M
  • Goutheraud, R
  • Drouet, J
  • Crouzel, C
  • Syrota, A
Type
Published Article
Journal
The International Journal of Applied Radiation and Isotopes
Publisher
Elsevier
Publication Date
Jan 01, 1985
Volume
36
Issue
1
Pages
63–67
Identifiers
PMID: 3882574
Source
Medline
License
Unknown

Abstract

Iodine-123 is produced via xenon-133 by irradiation of a sodium iodide target with 108 MeV deuterons from the synchrocyclotron of IPN. The on-line production method is described. The specific activity of the iodine is determined by neutron activation analysis and by a radioimmunological method. The conditions labelling different proteins (insulin, angiotensin) are given and also the purification method to obtain a product ready for injection to patients.

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