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The production of cytokines by polymorphonuclear neutrophils.

Authors
  • Cassatella, M A
Type
Published Article
Journal
Immunology Today
Publisher
Elsevier
Publication Date
Jan 01, 1995
Volume
16
Issue
1
Pages
21–26
Identifiers
PMID: 7880385
Source
Medline
License
Unknown

Abstract

Cytokines orchestrate the complex network of cellular interactions that regulate effector cell functions of natural and immune resistance. Although T cells, natural killer (NK) cells and monocytes/macrophages are the main producers of cytokines, a number of reports in the last few years have demonstrated that polymorphonuclear neutrophils (PMN) also have the ability to synthesize and release immunoregulatory cytokines. Here, Marco Cassatella describes novel facets of the regulation of cytokine production by PMN that highlight the involvement of of PMN in cell-cytokine crosstalk.

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