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Production of anti-W24 xenoantisera in rabbits.

Authors
  • Ferrone, S
  • Pellegrino, M A
  • Billing, R
  • Terasaki, P I
  • Reisfeld, R A
Type
Published Article
Journal
Tissue antigens
Publication Date
Feb 01, 1975
Volume
5
Issue
1
Pages
41–47
Identifiers
PMID: 1138440
Source
Medline
License
Unknown

Abstract

One out of four rabbits injected with partially purified soluble HL-A antigen from serum produced cytotoxic antibodies to human lymphocytes. These antibodies appear to be directed to the specificity W24 as determined by correlation studies with HL-A alloantisera and by absorption-inhibition experiments with human platelets and with serum soluble HL-A antigens. In the sera from the other three immunized rabbits, no antibodies to human lymphoid cells could be detected by the cytotoxic test, blocking of T cell rosette formation, stimulation of DNA synthesis and inhibition of mixed lymphocyte reaction.

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