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Production and possible function of serine protease during sporulation of Bacillus subtilis.

Authors
  • B N Dancer
  • J Mandelstam
Publication Date
Feb 01, 1975
Source
PMC
Keywords
License
Unknown

Abstract

The production of extracellular protease during sporulation in Bacillus subtilis 168 was investigated. Two proteases are produced, an alkaline serine protease and a neutral metalloprotease. In vivo inhibition of the serine protease with phenylmethylsulfonylfluoride indicated that the metalloprotease was degraded by the serine protease during sporulation. The experiments with phenylmethylsulfonylfluoride also show that the serine protease is necessary for the sequential process of sporulation and that it is required continuously for the first 2 to 3 h of the 8-h process.

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