Southern Tunisia is a region very prone to wind erosion because of its soil features, and the development of mechanized agriculture. Moreover, this region is located downwind the Sahara, which is the main source of mineral dust in the world. For these reasons, dust haze is frequently observed in this region. If some authors have already documented air quality in the northern part of Tunisia, no equivalent studies have ever been conducted for southern regions even though Dahech & Beltrando (2012) highlighted the potential negative impact of mineral dust on air quality in Sfax. This is why a ground-based station dedicated to the monitoring of mineral dust was installed at the Institut des Régions Arides (IRA) of Médenine to document the temporal variability of mineral dust concentrations in southern Tunisia. We present here the results from the two first years of measurements of meteorology, PM10 concentration, and direct solar radiation.