Affordable Access

deepdyve-link
Publisher Website

Probiotics for the Prevention of Antibiotic-associated Diarrhea in Adults: A Meta-Analysis of Randomized Placebo-Controlled Trials.

Authors
  • Liao, Wanqian1, 2
  • Chen, Chongxiang1, 2
  • Wen, Tianmeng3
  • Zhao, Qingyu1, 2
  • 1 Department of Intensive Care Unit.
  • 2 Infection Control Department, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou. , (China)
  • 3 School of Public Health, Sun Yat-Sen University, Guangzhou, Guangdong Province, People's Republic of China. , (China)
Type
Published Article
Journal
Journal of clinical gastroenterology
Publication Date
Jul 01, 2021
Volume
55
Issue
6
Pages
469–480
Identifiers
DOI: 10.1097/MCG.0000000000001464
PMID: 33234881
Source
Medline
Language
English
License
Unknown

Abstract

This meta-analysis aims to combine the latest research evidence to assess the effect of probiotics on preventing antibiotic-associated diarrhea (AAD) in adults. PubMed, Cochrane Library, EMBASE, and Web of Science were searched for randomized placebo-controlled trials on probiotics preventing AAD. A random or fixed effect model was used to combine the incidence of AAD (primary outcome) and the adverse event rates. The authors performed subgroup analyses to explore the effects of different participants population, probiotics species, and dosage. Thirty-six studies were included with 9312 participants. Probiotics reduced the incidence of AAD by 38% (pooled relative risk, 0.62; 95% confidence interval, 0.51-0.74). The protective effect of probiotics was still significant when grouped by reasons for antibiotics treatment, probiotic duration, probiotic dosage, and time from antibiotic to probiotic. However, there were no statistically significant increased adverse events in the probiotics group (relative risk, 1.00; 95% confidence interval, 0.87-1.14). This updated meta-analysis suggested that using probiotics as early as possible during antibiotic therapy has a positive and safe effect on preventing AAD in adults. Further studies should focus on the optimal dosage and duration of probiotics to develop a specific recommendation. Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc.

Report this publication

Statistics

Seen <100 times