Advanced practice registered nurses implement evidence-based care guidelines and assess the quality of care delivered to pediatric and adolescent populations to ensure that the highest standards of care are provided to the patients and their families. Standardized health care quality measures allow for assessment of clinical competence, monitoring of equitable health care distribution, improvement of provider/institutional accountability, development of standards for accreditation and certification, informing of quality improvement efforts, and creation of criteria for provider incentive payments. The purpose of this article is to explain why health care quality measures are established, what agencies oversee the development of meaningful pediatric quality measures, and how these measures inform and improve the care provided by pediatric-focused advanced practice registered nurses. Copyright © 2019 National Association of Pediatric Nurse Practitioners. Published by Elsevier Inc. All rights reserved.