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Prime-boost immunisation strategies for tuberculosis.

Authors
  • McShane, Helen1
  • Hill, Adrian
  • 1 Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK. [email protected]
Type
Published Article
Journal
Microbes and Infection
Publisher
Elsevier
Publication Date
May 01, 2005
Volume
7
Issue
5-6
Pages
962–967
Identifiers
PMID: 15890555
Source
Medline
License
Unknown

Abstract

Vaccines against intracellular pathogens such as Mycobacterium tuberculosis need to induce strong cellular immune responses. Heterologous prime-boost immunisation strategies induce higher levels of both CD4+ and CD8+ T cells than homologous boosting with the same vector. Recombinant pox-viruses are particularly good at boosting previously primed T cell responses. Using BCG as the priming immunisation in such a heterologous prime-boost strategy is a practical solution, which allows the beneficial effects of BCG in children to be maintained.

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