Affordable Access

Primary structure of somatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone.

Authors
  • Burgus, R
  • Ling, N
  • Butcher, M
  • Guillemin, R
Type
Published Article
Journal
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Publication Date
Mar 01, 1973
Volume
70
Issue
3
Pages
684–688
Identifiers
PMID: 4514982
Source
Medline
License
Unknown

Abstract

Somatostatin, a peptide isolated from ovine hypothalamic tissue that inhibits the release of radioimmunoassayable growth hormone in vitro from rat or human pituitary cells or in vivo in rats, has the primary structure [Formula: see text]. The structure was established by submitting the carboxymethylated peptide, the carboxymethylated tryptic digest, and the chymotryptic digest of the peptide to Edman degradation. Degradation products were analyzed by amino-acid analysis, as well as in some cases by determination of N-termini by dansylation or by determination of phenylthiohydantoins by mass spectrometry.

Report this publication

Statistics

Seen <100 times