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[Primary sclerosing cholangitis and autoimmune cochlear deafness: a new syndrome?].

Authors
  • Cohard, M
  • Rolachon, A
  • Vetter, D
  • Lejeune, J M
  • Stierle, J P
  • Fratte, S
  • Doffoël, M
  • Charachon, R
  • Zarski, J P
Type
Published Article
Journal
Gastroentérologie Clinique et Biologique
Publisher
Elsevier
Publication Date
Jan 01, 1993
Volume
17
Issue
5
Pages
391–394
Identifiers
PMID: 8349076
Source
Medline
License
Unknown

Abstract

Association of autoimmune cochlear hearing loss with primary sclerosing cholangitis is reported in two patients. Endocochlear sensorineural hearing loss was associated with the presence of anti-cochlear antibodies in the serum directed against the walls of vessels in the stria vascularis. The hearing loss appeared at the same time or shortly after the diagnosis of cholangitis. This association, which has never been described, may reinforce the theory of the role of immunologic factors in the pathogenesis of primary sclerosing cholangitis, possibly linked to or initiated by vasculitis.

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