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Primary hepatic carcinoid tumor.

Authors
  • Yasoshima, H
  • Uematsu, K
  • Sakurai, K
  • Ueno, Y
  • Hori, K
  • Kanazawa, N
  • Tanaka, T
  • Yamanaka, N
  • Okamoto, E
Type
Published Article
Journal
Acta pathologica japonica
Publication Date
Dec 01, 1993
Volume
43
Issue
12
Pages
783–789
Identifiers
PMID: 8109257
Source
Medline
License
Unknown

Abstract

A case of primary carcinoid tumor arising in the liver of a 69 year old woman with no endocrine symptoms is reported. Histopathologically, the tumor was diagnosed initially as a hepatocellular carcinoma in the biopsy specimen, and was shown subsequently to be a carcinoid tumor, demonstrating diffuse positive staining with Grimelius method. Mucin stained with periodic acid-Schiff (PAS), alcian-blue, and mucicarmine, and was shown partially in the glandular structures. Immunohistochemically, most of the tumor cells stained positively for chromogranin-A, epithelial membrane antigen (EMA) and neuron specific enolase (NSE). Ultrastructural examination revealed electron-dense core granules, measuring 40-120 nm in diameter in some of the tumor cells. Intensive and careful searches pre- and post-operatively revealed no other primary source of tumor other than the liver. The patient was reported well with no symptoms 3 1/2 years after the operation. This case is considered to be a primary hepatic carcinoid tumor. The recent literature is reviewed, and the possible histogenesis of hepatic carcinoid tumor is discussed.

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